The primary thrust of my research is to develop new tools and the knowledge necessary to rapidly and reliably discover novel enzyme catalysts. Research within the lab generally is focused around the use and development of computational modeling tools to evaluate how changes to a protein sequence, and therefore structure, results in a modulation of function. As members of the Rosetta Commons the majority of the modeling work carried out in the lab is done within the Rosetta Molecular Modeling Suite. We follow up the in silico modeling through in vitro studies leveraging recent breakthroughs from the field of synthetic biology to experimentally evaluate the properties of the designed proteins. On occasion we conduct in vivo studies of how the engineered proteins work within living organisms, however these studies are often done in collaboration with other groups. To date we have discovered and engineered enzymes to treat celiac disease, fight anthrax infections, catalyze novel chemistry never before observed in nature, produce high value chemicals, fixate carbon dioxide, and modulate the properties of various foods we eat. For more information, visit the Siegel Lab Website.
Awards, Education and Professional Highlights
Emmy Rossum and Justin Siegel
My scientific efforts are focused on combining computational and experimental tools to develop a fundamental knowledge of enzyme catalysis, and applying those principles to design novel proteins of therapeutic or commercial interest. Currently I am working with an international community on the development of Rosetta computational methodology for predicting and designing macromolecular structures, interactions, and functions. Using this methodology I have completed the de novo design of enzymes capable of catalyzing chemical reactions not found in nature, such as the Diels-Alder reaction. This was followed up by working with an online community, Foldit, to further engineer these proteins for enhanced activity. Most recently I have worked on the redesign of naturally occurring enzymes for the degradation of immunogenic gluten proteins, to develop a novel CO2 fixation pathways, and design of a novel anthrax therapeutic. My current focus is on the design of novel biofuel and commodity chemical biosynthetic pathways, the development of novel therapeutics, and the general understanding of the relationship between protein sequence, structure, and function. Justin Siegel. Home People Justin Siegel. Position Title.
Sign Up. Currently he works with an international community on the development of Rosetta computational methodology for predicting and designing macromolecular structures, interactions, and functions. Using this methodology he has successfully engineered and discovered numerous enzymes catalyzing a wide range of reactions. He has been the recipient of numerous awards, including the Sloan Research Fellowship in This article explores a lifelong collaboration between father, Brock Siegel and son, Justin Siegel, as each continues to learn, teach, and develop their science as well as share what they have learned through the course of their careers. Learn more about how the Siegel Lab at UC Davis is applying biology and innovation to address 21st Century challenges in the global food system and beyond.
Justin R. Siegel is a founding member and co-managing partner at Parq Advisors and specializes in life insurance strategies for ultra-affluent families across the business, sports and entertainment spectrums. Justin began his career as a professional baseball player, first with the Texas Rangers organization and later with the Boston Red Sox organization as a Rule V draft choice. After retiring from baseball following multiple arm surgeries, Justin became a consultant to young players just exiting professional baseball, helping them develop long-term financial and vocational strategies. Through conceptualizing, negotiating and executing strategic partnership opportunities, Justin contributed to the bottom line, helping to elevate the company from the private sector to the public markets. Currently, Justin sits on the executive board of the Water Buffalo Club, a non-profit organization comprised of 75 industry-leading executives from Beverly Hills, Century City, and Los Angeles areas.